Methyl Jasmonate - Clinical Results

A newly published paper reports the first clinical results from Methyl Jasmonate:

Eur Rev Med Pharmacol Sci. 2011 Mar;15(3):333-6.

A preliminary study of the local treatment of preneoplastic and malignant skin lesions using methyl jasmonate.

Palmieri B, Iannitti T, Capone S, Flescher E.

Source

Department of General Surgery and Surgical Specialties, University of Modena and Reggio Emilia Medical School, Surgical Clinic, Modena, Italy.

Abstract

BACKGROUND:

Jasmonates are plant stress hormones. These small hydrophobic compounds exhibit anti-cancer activities, in vitro and in vivo, against cancer cells of various histological origins. Moreover, they show a selective activity against transformed cells and affect drug-resistant cells as well.

AIM:

The aim of this study was to evaluate the activity of a powerful jasmonate derivative, that is methyl jasmonate.

MATERIAL AND METHODS:

Methyl jasmonate was applied topically on cancerous and pre-cancerous skin lesions from eight patients.

RESULTS:

Methyl jasmonate did not cause any meaningful local or systemic side effects. Three patients exhibited positive responses. Two patients had complete recovery and one had a recurrence of the lesion three months post treatment.

CONCLUSIONS:

Methyl jasmonate is a potentially promising novel topical treatment for prcancerous and cancerous skin lesions. Methyl jasmonate should be evaluated in a larger series of patients.

This is interesting and encouraging news.

It does lead me to ask the question: are there any readers of the original Grouppe Kurosawa who tried Methyl Jasmonate? The old blog was always short of people reporting back their experiences, yet we do know that lots of people did take Steve Martin's advice to try it.


If you want to help other people, then please report back your experiences - good, bad or indifferent. Please.

Flaxseed and Cancer

One of the anti-cancer agents that Steve Martin was interested in was Flax seed oil. He mentioned it on many posts and recommended it to cancer and HIV patients. It's interesting, therefore to see the following research being published recently:

Flaxseed oil-trastuzumab interaction in breast cancer.
Mason JK, Chen J, Thompson LU.


Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.

Abstract

Flaxseed oil (FO), which is rich in n-3 fatty acid, is commonly consumed by breast cancer patients because of its potential anti-cancer effects. Trastuzumab (TRAS) is the primary drug for epidermal growth factor receptor 2 (HER2) positive breast cancer. We investigated in athymic mice whether combining dietary FO (8%) with TRAS treatment (2.5 or 5mg/kg body weight) can cause better or adverse effect on established human breast tumors overexpressing HER2 (BT-474). Control tumors significantly grew 187%, TRAS2.5 treated tumors did not change, while TRAS5, FO+TRAS2.5 and FO+TRAS5 treated tumors significantly regressed 75%, 89% and 84%, respectively, after 4weeks treatment. Two weeks after stopping TRAS treatment while continuing on same diet, tumor size in FO+TRAS2.5 group was 87% lower than in TRAS2.5 group and was not different from TRAS5 group with or without FO. Combined TRAS2.5 treatment with FO caused a significantly lower tumor cell proliferation and higher apoptosis compared to TRAS2.5 treatment alone and showed similar effect to TRAS5 treatment with or without FO. Hence, FO did not interfere with TRAS but rather enhanced its tumor-reducing effects and combined FO and low dose TRAS was as effective as high dose TRAS treatment.

At the very least it suggests that Flaxseed and Flaxseed oil ought to be considered as strong anti-cancer foods. Worth discussing with your oncologist for sure...